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Researchers at Osaka University in Japan have made a groundbreaking discovery: hepatocyte growth factor (HGF) has the potential to slow down vascular aging. According to a recent report on the Asahi Shimbun website, experts believe that the formation and regeneration of blood vessels are closely linked to endothelial progenitor cells, which originate from myeloid cell differentiation. However, in individuals with diabetes or hypertension, damaged blood vessels often struggle to repair themselves.
In their study, researchers focused on patients with high blood pressure and found that angiotensin II (Ang II), a hormone associated with hypertension, accelerates the aging of endothelial progenitor cells, thereby weakening their ability to repair damaged vessels. Through experiments on mice, the team discovered that HGF can counteract the negative effects of Ang II, promoting the regeneration and formation of blood vessels. Additionally, HGF was found to enhance blood circulation in the experimental animals.
The researchers emphasize that in people with diabetes or high blood pressure, blood vessels tend to age more rapidly, increasing the risk of stroke and other cardiovascular diseases. This study suggests that HGF could be a promising therapeutic option for preventing vascular aging and reducing the likelihood of such serious health issues. Future research may explore how this protein can be harnessed to improve vascular health in humans, offering new hope for those at risk of stroke and related conditions.