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Researchers from Osaka University in Japan have recently uncovered a significant breakthrough in understanding vascular aging. According to reports from the Asahi Shimbun, scientists now believe that the formation and regeneration of blood vessels are closely linked to endothelial progenitor cells, which originate from myeloid cells. However, when individuals suffer from conditions like diabetes or hypertension, their ability to repair damaged blood vessels is severely compromised.
In this study, researchers focused on patients with high blood pressure and discovered that a hormone called Angiotensin II, known for causing hypertension, accelerates the aging of these endothelial progenitor cells, thereby reducing their regenerative capacity. Through experiments on mice, the team found that hepatocyte growth factor (HGF) can effectively counteract the harmful effects of Angiotensin II. This not only promotes the formation and repair of blood vessels but also enhances overall blood circulation in the experimental animals.
The findings suggest that vascular aging is a major contributor to serious health issues such as strokes, particularly in people with chronic conditions like diabetes and hypertension. The research indicates that HGF could be a promising therapeutic target for preventing vascular damage and reducing the risk of stroke. While more clinical trials are needed, this discovery opens up new possibilities for developing treatments aimed at maintaining healthy blood vessels and improving long-term cardiovascular outcomes.